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Synfacts 2010(3): 0337-0337  
DOI: 10.1055/s-0029-1219309
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ynones via Copper-Mediated Cross-Coupling of Alkynylboronates and Acid Chlorides

Contributor(s): Paul Knochel, Andreas J. Wagner
Y. Nishihara*, D. Saito, E. Inoue, Y. Okada, M. Miyazaki, Y. Inoue, K. Takagi
Okayama University, Japan
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Publication History

Publication Date:
18 February 2010 (online)

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Significance

In the presence of a copper(I) salt, cross-coupling reactions of alkynyl boronates with acid chlorides readily take place in aprotic solvents giving rise to the corresponding conjugated ynones in good yields. This reaction is a synthetically useful, straightforward carbon-carbon bond formation reaction using stable, non-toxic boron compounds.