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Synfacts 2010(3): 0323-0323  
DOI: 10.1055/s-0029-1219402
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Asymmetric Addition of Deactivated Grignard Reagents to Aldehydes

Contributor(s): Mark Lautens, David A. Candito
C.-S. Da*, J.-R. Wang, X.-G. Yin, X.-Y. Fan, Y. Liu, S.-L. Yu
Lanzhou University, P. R. of China
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Publication History

Publication Date:
18 February 2010 (online)

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Asymmetric Addition of Deactivated Grignard Reagents to AldehydesSynfacts 2010; 2010(05): 0618-0618
DOI: 10.1055/s-0029-1219763

Significance

The authors report a simplified protocol for the titanium-mediated asymmetric addition of Grignard reagents to aldehydes providing chiral secondary alcohols in good selectivity. The amount of titanium and ligand is reduced compared to earlier studies.