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Synfacts 2010(6): 0701-0701
DOI: 10.1055/s-0029-1219768
DOI: 10.1055/s-0029-1219768
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Palladium-Catalyzed Aerobic Cross-Coupling of Alkylzincs to Terminal Alkynes
M. Chen, X. Zheng, W. Li, J. He, A. Lei*
Wuhan University and Lanzhou Institute of Chemical Physics, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219768-1.jpg)
Significance
An operationally simple and efficient method for the construction of C(sp)-C(sp³) bonds from terminal alkynes and alkylzinc reagents via palladium-catalyzed oxidative coupling is disclosed. Air is used as the sole oxidant for this reaction, and the addition of carbon monoxide (1:10 by volume) has been found to increase the yield of the internal alkyne.