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Synfacts 2010(6): 0700-0700
DOI: 10.1055/s-0029-1219769
DOI: 10.1055/s-0029-1219769
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Two-Step Transition-Metal-Free Allylation of Grignard Reagents
X. Han, Y. Zhang, J. Wu*
Dartmouth College, Hanover, USA
Further Information
Publication History
Publication Date:
20 May 2010 (online)
Significance
A mild two-step procedure for the regioselective, transition-metal-free allylic substitution between Grignard reagents and phosphorothioate esters is reported. The latter are prepared in high yields from the corresponding allylic alcohols or methyl ethers.