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Synfacts 2010(6): 0693-0693
DOI: 10.1055/s-0029-1219776
DOI: 10.1055/s-0029-1219776
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Amide-Directed Olefination of sp³ C-H Bonds
M. Wasa, K. M. Engle, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219776-1.jpg)
Significance
A highly efficient protocol for the direct olefination of sp³ C-H bonds was developed. In this reaction, strongly electron-deficient amides serve as directing groups. The method could be applied to a wide variety of substrates, including even cyclopropyl methylene C-H bonds and compounds containing α-hydrogen atoms.