Download PDF
Synfacts 2010(6): 0707-0707  
DOI: 10.1055/s-0029-1219841
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Direct Amination of Aromatic C-H Bonds Using Oxime Esters

Contributor(s): Paul Knochel, Tobias Thaler
Y. Tan, J. F. Hartwig*
University of Illinois at Urbana-Champaign, USA
Further Information

Publication History

Publication Date:
20 May 2010 (online)

    Permissions and Reprints

Significance

A highly efficient sp² C-H amination using oxime esters is presented. The reaction is proposed to proceed via oxidative addition of the Pd(0) species into the N-O bond. Strong evidence is provided by an isolated Pd(II) complex generated from oxidative addition of Pd(0) into the N-O bond.