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Synfacts 2010(6): 0626-0626  
DOI: 10.1055/s-0029-1219853
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Phostriecin and Sultriecin

Contributor(s): Steven V. Ley, Philippa B. Cranwell
C. P. Burke, N. Haq, D. L. Boger*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
20 May 2010 (online)

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Significance

Phostriecin (originally called sultriecin) was isolated in 1992. The original structure was thought to be the analogous C9 sulfate ester (now called sultriecin). Synthesis of this proposed structure led to a distinct difference in the ¹H NMR spectrum. Therefore, the revised structure phostriecin was prepared and shown to match the data of the originally isolated natural product.