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Synfacts 2010(6): 0725-0725
DOI: 10.1055/s-0029-1219887
DOI: 10.1055/s-0029-1219887
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Propargylamines with Fe3O4 Nanoparticles
B. Sreedhar*, A. S. Kumar, P. S. Reddy
Indian Institute of Chemical Technology, Hyderabad, India
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219887-1.jpg)
Significance
Magnetically separable Fe3O4 nanoparticles catalyzed the three-component coupling of aldehydes 1, amines 2, and terminal alkynes 3 to afford the corresponding propargylamines 4 (18 examples, up to 92% yield, eq. 1). The reaction of 1,3-diethynylbenzene, cyclohexanecarboxaldehyde, and piperidine gave mono- and disubstituted products 4g and 4h in a ratio of 1:3 (eq. 2).