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Synfacts 2010(6): 0730-0730
DOI: 10.1055/s-0029-1219896
DOI: 10.1055/s-0029-1219896
Polymer-Supported Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Atom-Transfer Radical Cyclization with [Cu/bipy]@Si
Y. Motoyama, K. Kamo, A. Yuasa, H. Nagashima*
Kyushu University, Kasuga, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
20. Mai 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1219896-1.jpg)
Significance
A CuCl/bipyridine complex was immobilized in a polysiloxane gel which was prepared by treatment of polymethylhydrosiloxane with 4,4′-bis[(2-propenyl)oxy]-2,2′-bipyridine and 1,5-hexadiene (crosslinker) in the presence of Karstedt’s catalyst. The immobilized complex [Cu/bipy]@Si catalyzed the atom-transfer cyclization of N-vinyl- and N-allyl-α-halogenated acetamides to give the corresponding cyclized products in 58 to >99% yield (eq. 2, 10 examples).