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Synfacts 2010(6): 0679-0679
DOI: 10.1055/s-0029-1219901
DOI: 10.1055/s-0029-1219901
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic Asymmetric Conjugate Addition of Organozinc Reagents
K. Endo*, M. Ogawa, T. Shibata*
Waseda University, Tokyo, Japan
Further Information
Publication History
Publication Date:
20 May 2010 (online)
Significance
The authors developed a copper/zinc catalyst system that nicely catalyzes the conjugate addition to cyclic and acyclic enones. Having both copper and zinc centers, this system gives high reactivity and selectivity for the conjugate addition of organozinc reagents to enones. The new ligand design is particularly interesting and may be useful for other applications.