Synthesis of Pyrrolidines by Osmium-Catalyzed Oxidative Cyclization

T. J. Donohoe; P. J. Lindsay-Scott; J. S. Parker; C. K. A. Callens

doi:10.1055/s-0029-1219968

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Synfacts 2010(6): 0683-0683
DOI: 10.1055/s-0029-1219968

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Synthesis of Pyrrolidines by Osmium-Catalyzed Oxidative Cyclization

Contributor(s): Hisashi Yamamoto, Patrick Brady
T. J. Donohoe*, P. J. Lindsay-Scott, J. S. Parker, C. K. A. Callens
University of Oxford and AstraZeneca, Bristol, UK

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Publikationsverlauf

Publikationsdatum:
20. Mai 2010 (online)

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Significance

The described method allows for the construction of pyrrolidines by oxidative cyclization of amino alcohols that are formally derived from 1,4-dienes. Judicious choice of substrate geometry allows for the construction of both syn- and anti- pyrrolidines.