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Synfacts 2010(6): 0687-0687
DOI: 10.1055/s-0029-1219971
DOI: 10.1055/s-0029-1219971
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Copper-Catalyzed Asymmetric Michael Reaction of Glycines to Nitroalkenes
Q. Li, C.-H. Ding, X.-L. Hou*, L.-X. Dai
Shanghai Institute of Organic Chemistry, P. R. of China
Further Information
Publication History
Publication Date:
20 May 2010 (online)

Significance
In this paper the authors developed a highly diastereo- and enantioselective copper-catalyzed Michael addition of glycine derivatives to aryl nitroalkenes. The obtained adducts were converted into protected α,γ-diaminobutyric acids, which could be useful building blocks in natural product synthesis or biological studies.