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Synfacts 2010(6): 0716-0716
DOI: 10.1055/s-0029-1220003
DOI: 10.1055/s-0029-1220003
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
NHC-Catalyzed Hydroacylation of Unreactive Alkynes
A. T. Biju, N. E. Wurz, F. Glorius*
Westfälische Wilhelms-Universität Münster, Germany
Further Information
Publication History
Publication Date:
20 May 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1220003-1.jpg)
Significance
An intramolecular N-heterocyclic carbene (NHC) catalyzed hydroacylation of unactivated alkynes is described. In this paper, electron-rich alkynes are less reactive than electron-poor analogues, and less reactive alkynes are applied well to the cascade Stetter reaction. This work is the first example of a NHC-catalyzed cascade reaction involving the hydroacylation of unreactive alkynes without metal catalysts.