Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2010(6): 0709-0709
DOI: 10.1055/s-0029-1220005
DOI: 10.1055/s-0029-1220005
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Organocatalytic Carbocyclizations
first article: S. Rendler, D. W. C. MacMillan*, second article: R. R. Knowles, S. Lin, E. N. Jacobsen*
Princeton University, USA and Harvard University, Cambridge, USA
Further Information
Publication History
Publication Date:
20 May 2010 (online)
![](https://www.thieme-connect.de/media/synfacts/201006/lookinside/thumbnails/10.1055-s-0029-1220005-1.jpg)
Significance
The research groups of MacMillan and Jacobsen have developed examples of organocatalytic carbocyclizations. Rendler and MacMillan employed organo-SOMO catalysis for cyclizations of polyene aldehydes (e.g., 3). Polycycles (e.g., 4) were obtained in good yields and enantioselectivity with 30 mol% of secondary amine catalyst 1. Jacobsen and co-workers developed thiourea catalyst 2 which effects polycyclization of hydroxylactams (e.g., 5). Polycycles (e.g., 6) were obtained in moderate to good yields and enantiomeric ratios up to 97:3.