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Synfacts 2010(8): 0855-0855  
DOI: 10.1055/s-0030-1257766
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of ent-Abudinol B

Contributor(s): Steven V. Ley, Philippa B. Cranwell
M. A. Boone, R. Tong, F. E. McDonald*, S. Lense, R. Cao, K. I. Hardcastle
Emory University, Atlanta, USA
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Publikationsdatum:
22. Juli 2010 (online)

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Significance

Abudinol B was isolated from the sea sponge Ptilocaulis spiculifer. Abudinol B does not display any useful biological activity, but its unusual architecture renders it an interesting target. It is proposed that natural abudinol B is made from polycyclizations of squalene tetraepoxide ­involving two different cascade cyclization events.