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Synfacts 2010(8): 0955-0955  
DOI: 10.1055/s-0030-1257811
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Michael Reaction of α,α-Disubstituted Aldehydes and Maleimides

Contributor(s): Benjamin List, Anna Lee
F. Xue, L. Lu, S. Zhang, W. Duan*, W. Wang*
University of New Mexico, Albuquerque, USA; East China University of Science, Shanghai and Shanghai Institute of Materia Medica, P. R. of China
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Publikationsdatum:
22. Juli 2010 (online)

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Significance

An enantioselective Michael reaction of α,α-disubstituted aldehydes and maleimides has been reported. The biologically useful chiral disubstituted α-branched succinimides 1 were obtained in good yields and high enantio­selectivities under mild reaction conditions.