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Synfacts 2010(8): 0892-0892  
DOI: 10.1055/s-0030-1257833
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart ˙ New York

Trifluoromethylation of Terminal Alkynes

Contributor(s): Timothy M. Swager, Jeewoo Lim
L. Chu, F.-L. Qing*
Shanghai Institute of Organic Chemistry and Donghua Univerisity, Shanghai, P. R. of China
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

Compounds bearing trifluoromethyl groups are of interest in areas such as material chemistry and pharmaceuticals. Despite such widespread use of trifluoromethyl moieties, relatively few reliable methods of trifluoromethylation exist. Furthermore, trifluoromethylation of terminal alkynes have been a difficult task. The authors report an oxidative trifluoromethylation (1 → 2) with large substrate scope, which allows for a facile ­trifluoromethylation of terminal alkynes.