PDF herunterladen
Synfacts 2010(9): 0983-0983  
DOI: 10.1055/s-0030-1257929
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (+)-Sieboldine A

Contributor(s): Steven V. Ley, Philippa B. Cranwell
S. M. Canham, D. J. France, L. E. Overman*
University of California, Irvine, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
23. August 2010 (online)

    Lizenzen und Reprints

Significance

(+)-Sieboldine A was isolated from the club moss Lycopodium sieboldii and was shown to inhibit electric eel acetylcholinesterase. The structure is interesting due to the N-hydroxy-azacyclononane ring within the bicyclo[5.2.1]-­decane-N,O-acetal which was previously unknown.