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Synfacts 2010(9): 0979-0979  
DOI: 10.1055/s-0030-1257936
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of (S)-(+)-Tylophorine

Contributor(s): Steven V. Ley, Kimberley A. Roper
A. Stoye, T. Opatz*
University of Hamburg, Germany
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Publikationsdatum:
23. August 2010 (online)

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Significance

(S)-(+)-Tylophorine is a phenanthroindolizidine alkaloid that has been shown to arrest carcinoma cells in the G1 phase. The target, and other compounds from the family, have been synthesized previously using a variety of strategies including a Parham-type cyclization, a metal-catalyzed carbonylation, and metal-catalyzed cyclo­isomerization.