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Synfacts 2010(10): 1176-1176  
DOI: 10.1055/s-0030-1258598
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic SN2′-Selective Substitution of Allylic Chlorides with Arylboronic Esters

Contributor(s): Paul Knochel, Andreas J. Wagner
A. M. Whittaker, R. P. Rucker, G. Lalic*
University of Washington, Seattle, USA
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

A copper-catalyzed selective SN2′ arylation of allyl chlorides is achieved using aryl boronates as nucleophiles. The arylation products are obtained in high yield with various allyl chlorides and aryl boronates, tolerating a wide range of functional groups.