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Synfacts 2010(10): 1141-1141  
DOI: 10.1055/s-0030-1258647
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Diastereoselective Catalytic C-H Amination

Contributor(s): Mark Lautens, Norman Nicolaus
A. Nörder, P. Herrmann, E. Herdtweck, T. Bach*
Technische Universität München, Garching, Germany
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Publication History

Publication Date:
22 September 2010 (online)

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Significance

The metal-mediated direct amination through C-H bond insertion is a very powerful transformation. It usually requires a metal nitrene species which undergoes C-H insertion into the most nucleophilic C-H bond. Herein, the authors report their preliminary results of a diastereoselective version of this reaction applied to acyclic substrates of type 1, proceeding with an excellent degree of selectivity and high yields.