Regioselective C-H Borylation of Heteroarenes with
Silica-SMAP-Ir

S. Kawamorita; H. Ohmiya; M. Sawamura

doi:10.1055/s-0030-1258657

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Synfacts 2010(10): 1210-1210
DOI: 10.1055/s-0030-1258657

Polymer-Supported Synthesis

Regioselective C-H Borylation of Heteroarenes with Silica-SMAP-Ir

Contributor(s): Yasuhiro Uozumi, Tsubasa Muto
S. Kawamorita, H. Ohmiya, M. Sawamura*
Hokkaido University, Sapporo, Japan

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Publication History

Publication Date:
22 September 2010 (online)

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Significance

A silica-supported monophosphine iridium complex, silica-SMAP-Ir, catalyzed the regioselective C-H borylation of ester-functionalized heteroarenes 1 with bis(pinacolato)diboran (2) to give the corresponding 3-borylated heteroarenes 3 in up to 99% yield (eq. 1).