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Synfacts 2010(10): 1144-1144
DOI: 10.1055/s-0030-1258684
DOI: 10.1055/s-0030-1258684
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
New Ligand for Asymmetric Arylation of Aldehydes
A. Venturini Moro, E. R. T. Tiekink, J. Zuckerman-Schpector, D. S. Lüdtke, C. R. D. Correia*
Universidade Estadual de Campinas, Universidade Federal de São Carlos and Universidade de Sao Paulo, Brazil; University of Malaya, Kuala Lumpur, Malaysia
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. September 2010 (online)
Significance
A new proline-based ligand has been developed for the asymmetric arylation of aldehydes. The preparation of the catalyst is straightforward; the initial Heck arylation with arenediazonium salts in the presence of palladium proceeds nicely and further manipulation affords the final amino alcohol ligands. The diastereomers produced can easily be separated generating a useful ligand library.