Synthesis of a γ-Secretase Inhibitor

Significance

Both β- and γ-secretase are im­portant targets for the treatment of Alzheimer’s disease because of their central role in the production of β-amyloid peptide (Aβ). Extracellular accumulation of Aβ results in the formation of characteristic plaques leading to neurodegeneration, dementia, and death. The cis-2,6-disubstituted morpholine L is a lead γ-secretase inhibitor.