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Synfacts 2011(1): 0049-0049  
DOI: 10.1055/s-0030-1258989
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Modification of BINAP Ligand has Profound Effect in Intramolecular Heck Reactions

Contributor(s): Hisashi Yamamoto, Patrick Brady
D. A. Rankic, D. Lucciola, B. A. Keay*
University of Calgary, Canada
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

The BINAP ligand was modified at the 3,3′- and the P-positions. The modifications had a pronounced impact on enantioselectivity of some previously reported intramolecular Heck reactions with increased asymmetric induction observed in a number of cases.