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Synfacts 2011(1): 0048-0048  
DOI: 10.1055/s-0030-1259106
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Chiral α,β-Diamino Acids Using Copper(I)/TF-BiphamPhos

Contributor(s): Hisashi Yamamoto, Kimberly Griffin
G. Liang, M.-C. Tong, H. Tao, C.-J. Wang*
Wuhan University, P. R. of China
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Publikationsdatum:
21. Dezember 2010 (online)

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Significance

Having previously developed a chiral copper(I)/TF-BiphamPhos complex, the ­authors apply this catalyst to the Mannich reaction of N-tosylimines with a glycine-derived Schiff base. The chiral α,β-diamino acids synthesized are key biological compounds and synthetic building blocks in organic synthesis.