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Synfacts 2011(1): 0075-0075  
DOI: 10.1055/s-0030-1259114
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Ligand Controlled Cyclization for the Preparation of Heteroaromatics

Contributor(s): Paul Knochel, Andreas K. Steib
D. Tsvelikhovsky, S. L. Buchwald*
Massachusetts Institute of Technology, Cambridge, USA
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

Various vinyl diphenylamine intermediates are selectively cyclized to the corresponding five-, six- or seven-membered hetero­aromatics. The regioselectivity of these palladium-catalyzed cyclizations is almost exclusively directed by the used ligand.