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Synfacts 2011(1): 0074-0074  
DOI: 10.1055/s-0030-1259161
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Iridium-Catalyzed Enantioselective Hydrogenation of Quinoline Derivatives

Contributor(s): Hisashi Yamamoto, Zhi Li
F.-R. Gou, W. Li, X. Zhang*, Y.-M. Liang*
Rutgers, The State University of New Jersey, Piscataway and The Pennsylvania State University, University Park, USA; Lanzhou University, P. R. of China
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Publication History

Publication Date:
21 December 2010 (online)

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Significance

This paper describes an efficient hydrogenation procedure to afford enantioenriched hydrogenated quinoline derivatives. The same catalyst is also capable for the hydrogenation of quinoline N-oxide, although the conversion and enantioselectivity still need to be improved.