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Synfacts 2011(1): 0070-0070  
DOI: 10.1055/s-0030-1259164
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Copper-Catalyzed 1,6-Conjugate Addition to Cyclic Dienones

Contributor(s): Hisashi Yamamoto, Jiajing Tan
J. Wencel-Delord, A. Alexakis*, C. Crévisy*, M. Mauduit*
Université de Genève, Switzerland; Ecole Nationale Supérieure de Chimie de Rennes and Université Européenne de Bretagne, Rennes, France
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Publikationsdatum:
21. Dezember 2010 (online)

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Significance

The easily available diphenyl­phosphinoazomethinylate salt (DIPPAMs) ligand ­developed previously by this group (Tetrahedron: Asymmetry 2008, 19, 1804) is successfully applied to the copper(II)-catalyzed 1,6-conjugated addition between organozinc reagents and cyclic dienones with complete control of regioselectivity and high ee values.