Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2011(1): 0045-0045
DOI: 10.1055/s-0030-1259170
DOI: 10.1055/s-0030-1259170
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Propargylation of Benzaldehydes
D. L. Usanov, H. Yamamoto*
The University of Chicago, USA
Further Information
Publication History
Publication Date:
21 December 2010 (online)
Significance
The catalytic asymmetric Nozaki-Hiyama (NH) reaction provides direct access to useful chiral alcohols. Utilizing a novel chiral chromium catalyst, the authors report an efficient enantioselective propargylation of benzaldehyde derivatives, providing chiral homopropargyl alcohols with good yields and enantioselectivities.