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Synfacts 2011(1): 0073-0073  
DOI: 10.1055/s-0030-1259176
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Bifunctional Catalysts for Asymmetric Conjugate Addition

Contributor(s): Mark Lautens, David A. Candito
Y. Hasegawa, I. D. Gridnev, T. Ikariya*
Tokyo Institute of Technology, Japan
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Publikationsverlauf

Publikationsdatum:
21. Dezember 2010 (online)

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Significance

The authors report efficient and ­selective bifunctional chiral amido ruthenium and iridium complexes for the asymmetric conjugate addition of α-substituted cyanoacetates to acetylenic esters. Furthermore, spectroscopic and computational studies provide insight into catalytically relevant intermediates and transitions states.