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Synfacts 2011(6): 0692-0692  
DOI: 10.1055/s-0030-1260382
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Solid-Phase Synthesis of Polyamidoamines

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada, Maki Minakawa
D. Schaffert, N. Badgujar, E. Wagner*
Ludwig-Maximilians-Universität München, Germany
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

A solid-phase approach for the synthesis of polyamidoamines was developed. Fmoc-polyamino acid building blocks 7-10 were prepared by selective protection of oligoethylenimines, followed by introduction of a carboxylic acid using cyclic anhydrides and subsequent Fmoc protection. The Fmoc-polyamino acids led to the corresponding polyamidoamines 11-16 via Fmoc solid-phase peptide synthesis.