Download PDF
Synfacts 2011(6): 0647-0647  
DOI: 10.1055/s-0030-1260397
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Combined Rh/Au Catalysis to Form 2,5-Dihydrofurans

Contributor(s): Mark Lautens, Hasnain A. Malik
Ö. Aksin-Artok, N. Krause*
Technische Universität Dortmund, Germany
Further Information

Publication History

Publication Date:
19 May 2011 (online)

    Permissions and Reprints

Significance

2,5-Dihydrofurans have seen much interest from the chemical community due to their abundance as target molecules and their versatility as synthetic intermediates. The authors report a one-pot combined Rh(I)/Au(I) catalysis to afford 2,5-dihydrofurans from propargyloxiranes with poor to excellent diastereoselectivities. This method is shown to retain and transfer chirality with minimal loss of stereochemical information.