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Synfacts 2011(6): 0638-0638  
DOI: 10.1055/s-0030-1260436
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart ˙ New York

Rh(II)-Catalyzed Stereoselective Cross-Coupling of Diazo Compounds

Contributor(s): Hisashi Yamamoto, Zhi Li
J. H. Hansen, B. T. Parr, P. Pelphrey, Q. Jin, J. Autschbach, H. M. L. Davies*
Emory University, Atlanta and University at Buffalo, The State University of New York, USA
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Publication History

Publication Date:
19 May 2011 (online)

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Significance

Efficient synthesis of alkenes with high E/Z-selectivity is a very important yet difficult problem for organic synthesis. In this paper, a very interesting direct stereoselective cross-coupling reaction of two diazo compounds is introduced with a dirhodium tetrakis pivaloate catalyst. In many cases the reaction gave greater than 20:1 E-stereoselectivity.