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Synfacts 2011(8): 0905-0905
DOI: 10.1055/s-0030-1260838
DOI: 10.1055/s-0030-1260838
Organo- and Biocatalysis
© Georg Thieme Verlag
Stuttgart ˙ New York
Catalytic Asymmetric Synthesis of Trisub-stituted Aziridines
first article: L. Huang, W. D. Wulff*, second article: T. Hashimoto, H. Nakatsu, K. Yamamoto, K. Maruoka*
Michigan State University, East Lansing, USA and Kyoto University, Japan
Further Information
Publication History
Publication Date:
20 July 2011 (online)
Significance
The groups of Wulff and Maruoka independently report the catalytic asymmetric synthesis of trisubstituted aziridines using chiral Brønsted acid catalysts. Wulff’s aziridination was induced by Lewis acid assisted chiral Brønsted acid catalysts derived from VANOL 1a or VAPOL 1b. The Maruoka group used the strong chiral Brønsted acid catalyst 2. In both cases, the desired products were obtained in high diastereo- and enantioselectivities.