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Synfacts 2011(8): 0905-0905  
DOI: 10.1055/s-0030-1260838
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Catalytic Asymmetric Synthesis of Trisub-stituted Aziridines

Contributor(s): Benjamin List, Anna Lee
first article: L. Huang, W. D. Wulff*, second article: T. Hashimoto, H. Nakatsu, K. Yamamoto, K. Maruoka*
Michigan State University, East Lansing, USA and Kyoto University, Japan
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Publikationsverlauf

Publikationsdatum:
20. Juli 2011 (online)

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Significance

The groups of Wulff and Maruoka independently report the catalytic asymmetric synthesis of trisubstituted aziridines using chiral Brønsted acid catalysts. Wulff’s aziridination was induced by Lewis acid assisted chiral Brønsted acid catalysts derived from VANOL 1a or VAPOL 1b. The Maruoka group used the strong chiral Brønsted acid catalyst 2. In both cases, the desired products were obtained in high diastereo- and enantioselectivities.