Synlett 2015; 26(06): 785-790
DOI: 10.1055/s-0034-1380120
letter
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Tandem Reactions of 2-Iodobenzamides with Sodium Azide: An Efficient Synthesis of [1,2,3]Triazolo[1,5-a][1,4]-benzodiazepin-6(5H)-ones

Wanli Chen
a   Center of Analysis & Measurement, Zhejiang University of Technology, Hangzhou 310014, P. R. of China,
,
Haitao Li
a   Center of Analysis & Measurement, Zhejiang University of Technology, Hangzhou 310014, P. R. of China,
,
Xiaoling Gu
a   Center of Analysis & Measurement, Zhejiang University of Technology, Hangzhou 310014, P. R. of China,
,
Yinghong Zhu*
b   College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P. R. of China   eMail: yhzhuchem@zjut.edu.cn
› Institutsangaben
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Publikationsverlauf

Received: 28. November 2014

Accepted after revision: 27. Dezember 2014

Publikationsdatum:
05. Februar 2015 (online)


Abstract

Copper-catalyzed tandem reactions between 2-iodobenzamides with a propargyl group on the nitrogen atom moiety and sodium azide are presented, providing an efficient method for the synthesis of 3-substituted [1,2,3]triazolo[1,5-a][1,4]benzodiazepin-6(5H)-ones under mild conditions in moderate yields.

Supporting Information