Recent Advances in the Synthesis of 2-Substituted Oxetanes

Abstract

Recent interest in oxetanes in medicinal chemistry and as synthetic intermediates has led to the development of a number of methods for the synthesis of more functionalized and highly substituted oxetane derivatives. Here we review cyclization approaches for the preparation of 2-substituted oxetanes. Methods involving C–O bond formation, as well as recently developed C–C bond forming cyclization strategies are highlighted.

Key words

Oxetanes - Heterocycles - Cyclization - Ethers - Insertion

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