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Synthesis 2019; 51(10): 2183-2190
DOI: 10.1055/s-0037-1611724
DOI: 10.1055/s-0037-1611724
paper
Trichloroisocyanuric Acid Mediated High-Yielding Synthesis of N-Acylbenzotriazoles under Mild Reaction Conditions
Science and Engineering Research Board (SERB), New Delhi (Grant No. EMR/2016/001123).Further Information
Publication History
Received: 23 November 2018
Accepted after revision: 10 January 2019
Publication Date:
20 February 2019 (online)
![](https://www.thieme-connect.de/media/synthesis/201910/lookinside/thumbnails/ss-2018-z0786-op_10-1055_s-0037-1611724-1.jpg)
This manuscript is dedicated to the (Late) Prof. Alan R. Katritzky for his contributions to benzotriazole chemistry.
Abstract
N-Acylbenzotriazoles are achieved in good yields from the corresponding carboxylic acids by using only 0.35 equivalent of trichloroisocyanuric acid and 1.2 equivalents of PPh3. The salient features of the developed reaction path include an economic, facile, base-free, and equally useful method in milligram to gram scale.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611724. Included are copies of 1H and 13C NMR spectra for all the developed N-acylbenzotriazoles for this article.
- Supporting Information
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