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Thromb Haemost 2002; 87(01): 42-46
DOI: 10.1055/s-0037-1612941
Review Article
Schattauer GmbH

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome[*]

Catharina Suharti
1   Departments of Medicine and
,
Eric C.M. van Gorp
2   Department of Medicine, Slotervaart Hospital, Amsterdam
,
Tatty E. Setiati
3   Paediatrics, Faculty of Medicine, Diponegoro University and Dr. Kariadi Hospital, Semarang, Indonesia
,
Wil M.V. Dolmans
4   Department of Medicine, University Medical Centre St. Radboud, Nijmegen
,
Robert J. Djokomoeljanto
1   Departments of Medicine and
,
C. Erik Hack
5   Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Department Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam
,
Hugo ten Cate
6   Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands
,
Jos W.M. van der Meer
4   Department of Medicine, University Medical Centre St. Radboud, Nijmegen
› Author Affiliations
Further Information

Publication History

Received 12 June 2001

Accepted 01 October 2001

Publication Date:
13 December 2017 (online)

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Summary

In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor-a (TNF-a), interleukin-1f3 (IL-1f3), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-a, IL-1f3 and Il-1Ra, but not IL-6, concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital. TNF-a was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. IL-1f3 was significantly associated with t-PA (p < 0.03). IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively), whereas IL-6 was significantly associated with both, activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis.

Keywords

Cytokines - coagulation - fibrinolysis - dengue shock syndrome

* Financial support: Royal Netherlands Academy of Arts and Sciences (KNAW).


 

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