The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome

Catharina Suharti; Eric C.M. van Gorp; Tatty E. Setiati; Wil M.V. Dolmans; Robert J. Djokomoeljanto; C. Erik Hack; Hugo ten Cate; Jos W.M. van der Meer

doi:10.1055/s-0037-1612941

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 2002; 87(01): 42-46
DOI: 10.1055/s-0037-1612941

Review Article

Schattauer GmbH

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome^[*]

Catharina Suharti

¹Departments of Medicine and

,

Eric C.M. van Gorp

²Department of Medicine, Slotervaart Hospital, Amsterdam

,

Tatty E. Setiati

³Paediatrics, Faculty of Medicine, Diponegoro University and Dr. Kariadi Hospital, Semarang, Indonesia

,

Wil M.V. Dolmans

⁴Department of Medicine, University Medical Centre St. Radboud, Nijmegen

,

Robert J. Djokomoeljanto

¹Departments of Medicine and

,

C. Erik Hack

⁵Central Laboratory of The Netherlands Red Cross Blood Transfusion Service and Department Clinical Chemistry, Academic Hospital Vrije Universiteit, Amsterdam

,

Hugo ten Cate

⁶Laboratory for Experimental Internal Medicine, Academic Medical Centre, Amsterdam, The Netherlands

,

Jos W.M. van der Meer

⁴Department of Medicine, University Medical Centre St. Radboud, Nijmegen

› Institutsangaben

Abstract

Summary

In a prospective clinical study of 50 patients with Dengue Shock Syndrome (DSS), we investigated the association of tumor necrosis factor-a (TNF-a), interleukin-1f3 (IL-1f3), IL-1 receptor antagonist (IL-1Ra), and IL-6 with activation markers of coagulation (F1+2 and TATc) and fibrinolysis (t-PA, PAPc, and D-dimer). We found that TNF-a, IL-1f3 and Il-1Ra, but not IL-6, concentrations were elevated in the circulation during the early stage of infection and at discharge from hospital. TNF-a was significantly associated with D-dimer, an activation marker of fibrinolysis (p < 0.003), but not with activation markers of coagulation. IL-1f3 was significantly associated with t-PA (p < 0.03). IL-1Ra was significantly associated with F1+2, TATc (p < 0.04 and p < 0.02, respectively), whereas IL-6 was significantly associated with both, activation markers of coagulation (F1+2; p < 0.03) and fibrinolysis (PAPc; p = 0.002). Our data are in line with studies in bacterial sepsis. In severe dengue virus infection the same cytokines are involved in the onset and regulation of hemostasis.

Keywords

Cytokines - coagulation - fibrinolysis - dengue shock syndrome

Volltext

Referenzen

References
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The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome[*]

The Role of Cytokines in Activation of Coagulation and Fibrinolysis in Dengue Shock Syndrome^[*]