Iridium-Catalyzed Asymmetric C–H Borylation Enabled by Chiral Bidentate Boryl Ligands

Abstract

Asymmetric synthesis of optically pure organoboron compounds is a topic that has received a number of attentions owing to their particular importance in synthetic chemistry and drug discovery. We herein highlight recent advances in the iridium-catalyzed C–H borylation of diarylmethylamines and cyclopropanes enabled by chiral bidentate boryl ligands.

1 Introduction

2 Ir-Catalyzed Asymmetric C(sp²)–H Borylation of Diarylmethylamines

3 Ir-Catalyzed Enantioselective C(sp³)–H Borylation of Cyclopropanes

4 Conclusion

Key words

chiral boryl ligand - C–H borylation - asymmetric C–H activation - diarylmethylamine - cyclopropane - iridium - asymmetric catalysis

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