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CC BY 4.0 · Synlett 2020; 31(13): 1244-1258
DOI: 10.1055/s-0039-1690904
DOI: 10.1055/s-0039-1690904
account
The Problem with Problems: Fundamental to Applied Research Using Palladium
The studies are very grateful for the support we have received from the following sources for the chemistry described in this Account: EPSRC (EP/R025754/1), The Leverhulme Trust (RPG-2015-308), and GlaxoSmithKline and AstraZeneca for several CASE awards and iCASE studentships.Further Information
Publication History
Received: 18 February 2020
Accepted after revision: 01 April 2020
Publication Date:
05 May 2020 (online)
Dedicated to our co-workers and collaborators, past, present, and future
Abstract
This Account describes the development of our cross-coupling and medicinal chemistry research from its origins at the outset of my independent career through to the present day. Throughout, the decisions and motivations as well as the mistakes and pitfalls are discussed.
1 Introduction
2 Hobbies and Interests
3 Scooped before Starting
4 Opportunity from Collaboration
5 Chemoselective Suzuki–Miyaura Cross-Coupling
6 Applications to the Medicinal Chemistry Campaign
7 Autotaxin and Heterocycle Synthesis
8 ATX Hybrids and Pd(II) Speciation
9 Conclusions
-
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For reviews, see:
For a selection of this work, see:
For reviews, see:
For examples, see:
For examples, see:
For examples, see:
For informative studies on the esterification of boronic acids, see:
For initial reports, see:
For selected reviews, see:
For selected examples, see: