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DOI: 10.1055/s-0040-1707241
Metal-Free Catalytic Aromatic C–H Borylation
This work was supported by the grants from the National Natural Science Foundation of China (21602096).Publication History
Received: 19 June 2020
Accepted after revision: 10 July 2020
Publication Date:
11 August 2020 (online)
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Abstract
In recent decades, C–H borylation has undergone rapid development and has become one of the most important and efficient methods for the synthesis of organoboron compounds. Although transition-metal catalysis dominates C–H borylation, the metal-free approach has emerged as a promising alternative strategy. This article briefly summarizes the history of metal-free aromatic C–H borylation, including early reports on electrophilic C–H borylation and recent progress in metal-free catalytic intermolecular C–H borylation; it also highlights our recent work on BF3·Et2O-catalyzed C2–H borylation of hetarenes. Despite these recent advances, comprehensive mechanistic studies on various metal-free catalytic aromatic C–H borylations and novel processes with a wider substrate scope are eagerly expected in the near future.
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For a review of intramolecular (directed) electrophilic C–H borylation, see:
For examples of intramolecular (directed) electrophilic C–H borylation, see:
For examples of intramolecular (directed) electrophilic C–H borylation towards the synthesis of BN-fused and boron-doped polycyclic aromatics, see:
For examples of catalytic intramolecular electrophilic C–H borylation catalyzed by HNTf2 and [Ph3C]+[B(C6F5)4]–, see: