A β-Lactone for Covalent Inhibition of KRAS G12S

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Synfacts 2022; 18(10): 1141
DOI: 10.1055/s-0041-1738592

Innovative Drug Discovery and Development

Contributor(s):

Dirk Trauner

,

Klaus-Peter Ruehmann

cancer - covalent inhibition - nucleophile-catalyzed aldol lactonization (NCAL)

Article published online:
20 September 2022

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany