Ligand-Promoted Rosenmund–von Braun Reaction

Abstract

Two picolinamide ligands were found to have significant accelerating effect to classical Rosenmund–von Braun reaction, making the coupling of (hetero)aryl bromides with CuCN occur at 100–120 °C with good to excellent yields in most cases. A large number of functional groups and heterocycles were tolerated under these conditions, thereby providing a convenient and reliable approach for diverse synthesis of aryl nitriles.

Key words

aryl nitriles - cyanation - coupling reaction - ligand - copper cyanide

Publication History

Received: 29 April 2022

Accepted after revision: 17 January 2023

Article published online:
09 February 2023

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