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Synlett 2004(10): 1707-1710
DOI: 10.1055/s-2004-829573
DOI: 10.1055/s-2004-829573
LETTER
© Georg Thieme Verlag Stuttgart · New York
An Efficient and Novel Protocol for the Synthesis of Pyrazolo[5,1-a]isoindole Derivatives
Weitere Informationen
Publikationsverlauf
Received
29 January 2004
Publikationsdatum:
15. Juli 2004 (online)


Abstract
Fused pyrazole systems are biologically important molecules. An efficient two-step protocol has been developed to make new molecules of this family via the reaction between dimethyl acetylenedicarboxylate, triphenylphosphine and N-aminophthalimide in the presence of benzoic acid or N-aminophthalimide derivatives. This reaction occurred easily in an ambient temperature to give stable phosphorus ylides, which, upon heating, underwent an intramolecular Wittig reaction to afford the pyrazolo[5,1-a]isoindole derivatives.
Key words
dimethyl acetylenedicarboxylate - pyrazolo[5,1-a]isoindole - Wittig reaction