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Synlett 2005(3): 445-448
DOI: 10.1055/s-2005-862372
DOI: 10.1055/s-2005-862372
LETTER
© Georg Thieme Verlag Stuttgart · New York
Practical Protocol for the Palladium-Catalyzed Synthesis of Arylphosphonates from Bromoarenes and Diethyl Phosphite
Weitere Informationen
Publikationsverlauf
Received
23 November 2004
Publikationsdatum:
04. Februar 2005 (online)


Abstract
A greatly improved, reliable protocol for the palladium-catalyzed cross-coupling of dialkyl phosphites with aryl bromides has been developed. The use of an alcoholic solvent was the key to high yields in the synthesis of a broad variety of arylphosphonates, with Pd(OAc)2/PPh3 as the catalyst and a sterically demanding tertiary amine as the base.
Key words
palladium - catalysis - arylphosphonates - cross-coupling - aryl halides