Synlett 2005(3): 445-448  
DOI: 10.1055/s-2005-862372
LETTER
© Georg Thieme Verlag Stuttgart · New York

Practical Protocol for the Palladium-Catalyzed Synthesis of Arylphosphonates from Bromoarenes and Diethyl Phosphite

Lukas J. Gooßen*, Mohammad K. Dezfuli
Max-Planck Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany
Fax: +49(241)8093663; e-Mail: goossen@oc.rwth-aachen.de;
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Publikationsverlauf

Received 23 November 2004
Publikationsdatum:
04. Februar 2005 (online)

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Abstract

A greatly improved, reliable protocol for the palladium-catalyzed cross-coupling of dialkyl phosphites with aryl bromides has been developed. The use of an alcoholic solvent was the key to high yields in the synthesis of a broad variety of arylphosphonates, with Pd(OAc)2/PPh3 as the catalyst and a sterically demanding ­tertiary amine as the base.