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Synfacts 2005(3): 0346-0346  
DOI: 10.1055/s-2005-921647
Bioorganic Chemistry and Organocatalysis
© Georg Thieme Verlag Stuttgart · New York

A One-Pot Synthesis of Chiral Dihydro-1,2-oxazines

Contributor(s): Benjamin List, Subhas Chandra Pan
S. Kumarn, D. M. Shaw, D. A. Longbottom, S. V. Ley*
University of Cambridge, UK
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Publikationsdatum:
22. November 2005 (online)

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Significance

1,2-Oxazines are important scaffolds present in bioactive natural products. The authors present a one-pot synthesis of chiral dihydro-1,2-oxazines using a proline-derived tetrazole catalyst. Good yields and excellent ee’s are obtained for a number of different aldehydes.