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Synfacts 2006(1): 0003-0003  
DOI: 10.1055/s-2005-921656
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of BMS-594726

Contributor(s): Philip Kocienski
H. D. King*, Z. Meng*, D. Denhart, R. Mattson, R. Kimura, D. Wu, Q. Gao, J. E. Macor
Bristol Myers Squibb, Walingford, Connecticut, USA
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

BMS-594726 is a potent and selective serotonin reuptake inhibitor that may be useful for the treatment of depression. The Bristol Myers Squibb synthesis features the first example of an enantioselective conjugate addition of indoles with an α-branched α,β-unsaturated aldehyde using imidazolidinone catalysis.