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Synfacts 2006(1): 0066-0066  
DOI: 10.1055/s-2005-921727
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cyclopropanes from Homoallylic Iodides and 1,3-Dihalopropanes

Contributor(s): Paul Knochel, Andrei Gavryushin
D. Sakuma, H. Togo*
Chiba University, Japan
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Publication History

Publication Date:
16 December 2005 (online)

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Significance

Cyclopropanes are widespread structural units occurring in many natural and synthetic compounds and possessing biological activity. This method affords an easy approach to a broad range of polyfunctionalized cyclopropanes, starting from readily available acyclic precursors. The cyclopropane ring was formed by a radical cyclization, which is somewhat uncommon.